April 2024 PPARG-High Circulating Monocytes Exhibit An Immunosuppressive Phenotype In Urothelial Cancer Patients Treated with Anti-PD1 VIEW POSTER
January 2024 A Phase 1, First-in-Human, Dose-Escalation and Expansion Study of FX-909 in Patients with Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma 2024 ASCO Genitourinary Cancers Symposium VIEW POSTER
November 2023 PPARG Amplification is Associated with Lack of Response to Anti-PD1 in Muscle-Invasive Urothelial Cancer Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting VIEW POSTER
October 2023 AI Analysis of Histological Images Accurately Identifies Luminal Subtype Urothelial Carcinomas Characterized by High PPARG Expression 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics VIEW POSTER
April 2023 Development of a surrogate tissue pharmacodynamic (PD) assay for potential clinical use with FX-909, a novel inhibitor of the urothelial luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) American Association for Cancer Research (AACR Annual Meeting) VIEW POSTER
October 2022 Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium) VIEW POSTER
October 2022 Peroxisome proliferator-activated receptor gamma (PPARG) status defines the luminal lineage in molecular profiles of advanced urothelial cancers (UC) European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium) VIEW POSTER
January 2021 Nat Biotechnol: Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP. 2021 Jan 4. doi: 10.1038/s41587-020-00778-3. Online ahead of print. VIEW PAPER
April 2019 Nat Chem Biol: Bidirectional modulation of HIF-2 activity through chemical ligands. Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim X, Khorasanizadeh S, Rastinejad F. 2019 Apr;15(4):367-376. doi: 10.1038/s41589-019-0234-5. Epub 2019 Feb 25. VIEW PAPER
February 2018 Cell: The Human Transcription Factors. Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen S, Taipale J, Hughes TR, Weirauch MT. 2018 Feb 8;172(4):650-665. doi: 10.1016/j.cell.2018.01.029. VIEW PAPER
