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May 2024

Genomic peroxisome proliferator-activated receptor gamma (PPARG) study: A sponsored testing program to identify patients harboring genetic alterations in advanced UC in support of the FX-909 Phase 1 study

AACR Special Conference in Cancer Research: Bladder Cancer: Transforming the Field
April 2024

PPARG-High Circulating Monocytes Exhibit An Immunosuppressive Phenotype In Urothelial Cancer Patients Treated with Anti-PD1

American Association for Cancer Research (AACR Annual Meeting)
January 2024

A Phase 1, First-in-Human, Dose-Escalation and Expansion Study of FX-909 in Patients with Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma

2024 ASCO Genitourinary Cancers Symposium
November 2023

PPARG Amplification is Associated with Lack of Response to Anti-PD1 in Muscle-Invasive Urothelial Cancer

Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting
October 2023

AI Analysis of Histological Images Accurately Identifies Luminal Subtype Urothelial Carcinomas Characterized by High PPARG Expression

2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
April 2023

Development of a surrogate tissue pharmacodynamic (PD) assay for potential clinical use with FX-909, a novel inhibitor of the urothelial luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG)

American Association for Cancer Research (AACR Annual Meeting)
October 2022

Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models

European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium)
October 2022

Peroxisome proliferator-activated receptor gamma (PPARG) status defines the luminal lineage in molecular profiles of advanced urothelial cancers (UC)

European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium)
January 2021

Nat Biotechnol: Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries.

Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP. 2021 Jan 4. doi: 10.1038/s41587-020-00778-3. Online ahead of print.
April 2019

Nat Chem Biol: Bidirectional modulation of HIF-2 activity through chemical ligands. 

Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim X, Khorasanizadeh S, Rastinejad F. 2019 Apr;15(4):367-376. doi: 10.1038/s41589-019-0234-5. Epub 2019 Feb 25.
February 2018

Cell: The Human Transcription Factors.

Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen S, Taipale J, Hughes TR, Weirauch MT. 2018 Feb 8;172(4):650-665. doi: 10.1016/j.cell.2018.01.029.

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