Publications

A Phase 1, First-in-Human, Dose-Escalation and Expansion Study of FX-909 in Patients with Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
2024 ASCO Genitourinary Cancers Symposium
January, 2024

PPARG Amplification is Associated with Lack of Response to Anti-PD1 in Muscle-Invasive Urothelial Cancer
Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting
November, 2023

AI Analysis of Histological Images Accurately Identifies Luminal Subtype Urothelial Carcinomas Characterized by High PPARG Expression
2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
October, 2023

Development of a surrogate tissue pharmacodynamic (PD) assay for potential clinical use with FX-909, a novel inhibitor of the urothelial luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG)
American Association for Cancer Research (AACR Annual Meeting)
April, 2023

Peroxisome proliferator-activated receptor gamma (PPARG) status defines the luminal lineage in molecular profiles of advanced urothelial cancers (UC)
European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium)
October, 2022

Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models
European Organisation for Research and Treatment of Cancer (34th EORTC-NCI-AACR Symposium)
October, 2022

Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen S, Taipale J, Hughes TR, Weirauch MT. The Human Transcription Factors. Cell. 2018 Feb 8;172(4):650-665. doi: 10.1016/j.cell.2018.01.029.

Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim X, Khorasanizadeh S, Rastinejad F. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376. doi: 10.1038/s41589-019-0234-5. Epub 2019 Feb 25.

Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP. Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 Jan 4. doi: 10.1038/s41587-020-00778-3. Online ahead of print.

 

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