Press Releases

10.25.2021
Company expands leadership team across business and science as it advances precision oncology pipeline

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05.13.2021
Company has pioneered ‘switch site’ approach to uncover druggable regions within well validated, but elusive, transcription factors that are master regulators of gene expression

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Publications

Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen S, Taipale J, Hughes TR, Weirauch MT. The Human Transcription Factors. Cell. 2018 Feb 8;172(4):650-665. doi: 10.1016/j.cell.2018.01.029.

Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim X, Khorasanizadeh S, Rastinejad F. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376. doi: 10.1038/s41589-019-0234-5. Epub 2019 Feb 25.

Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP. Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 Jan 4. doi: 10.1038/s41587-020-00778-3. Online ahead of print.

 

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